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Tricyclic Antidepressants - Side-Effects

Abstract: Trycyclics can cause stomach upset, constipation, dry mouth, blurred vision, drowsiness,lowered blood pressure (fainting), weight gain, tremors, sweating, problems urinating, problems having orgasm, confusion in elderly people, cardiac problems.

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Tricyclic Antidepressants - Side-Effects

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Written by: , lecturer of Psychiatry in the University of Ioannina Medical School, Greece. Eva Gerasi, postgraduate student in the Department of Psychiatry, University Hospital of Ioannina, Greece.
First version: 22 Jul 2008.
Latest revision: 29 Jul 2008.

What are the side-effects for TCAs?


Side effects may vary among these medications, and most of them lessen as the person continues to take the medication. Side effects include:
  • Stomach upset and other problems, such as constipation.
  • Dry mouth, blurred vision, and drowsiness.
  • Lowered blood pressure.
  • Weight gain.
  • Tremors and sweating.
  • Inability to urinate (urinary retention).
  • Loss of sexual desire or ability.
  • Confusion or delirium in older adults.
The most important side effects include cardiac problems in those with previous heart disease. They may be fatal in overdose.
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