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Other Antidepressants - Nefazodone

Abstract: What is nefazodone? How does it work? What are its side effects?

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Other Antidepressants - Nefazodone

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Written by: , lecturer of Psychiatry in the University of Ioannina Medical School, Greece. Eva Gerasi, postgraduate student in the Department of Psychiatry, University Hospital of Ioannina, Greece.
First version: 22 Jul 2008.
Latest revision: 22 Jul 2008.

What is nefazodone? How does it work? What are its side effects?


Nefazodone is a mixed selective serotonin reuptake inhibitor and 5HT2 receptor antagonist. It is as effective in treating depression as SSRIs.

It has side effects similar to those of selective serotonin reuptake inhibitors (SSRIs). The most common side effects of nefazodone are:

  • Dry mouth
  • Blurred vision
  • Constipation
  • Low blood pressure when standing
Additional negative side effects of nefazodone are possible but rare. They include allergic reaction, nausea, ringing in the ears, headaches, insomnia, and possibly seizures. It is free of gastrointestinal side effects and the sexual dysfunction seen with SSRIs. It is more sedative so it helps sleep, but it causes some postural hypotension.

Nefazodone hydrochloride should not be taken if the patient has had a previous allergic reaction to this medication. It should also not be used if they are taking a MAOI.

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