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Klomipramine (Anafranil) - Side-effects

Abstract: Clomipramin can cause tiredness, dissiness, dry mouth, dry eyes, constipation, sweating, agitation, headache, weight loss and other side effects.

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Klomipramine (Anafranil) - Side-effects

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Written by: , lecturer of Psychiatry in the University of Ioannina Medical School, Greece. Eva Gerasi, postgraduate student in the Department of Psychiatry, University Hospital of Ioannina, Greece.
First version: 22 Jul 2008.
Latest revision: 29 Jul 2008.

What are the possible side effects of clomipramine (Anafranil)?


If you experience any of the following serious side effects, stop taking clomipramine and your doctor immediately or seek emergency medical treatment:

  • an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, face, or tongue; or hives);
  • seizures;
  • a fast or irregular heartbeat;
  • a heart attack;
  • high blood pressure (blurred vision, severe headache);
  • difficulty urinating; or
  • fever with increased sweating, muscle stiffness, or severe muscle weakness.

Other, less serious side effects may be more likely to occur. Continue to take clomipramine and talk to your doctor if you experience:

  • sexual problems; More info.
  • drowsiness or dizziness;
  • dry mouth and eyes;
  • constipation;
  • mild tremor;
  • sweating;
  • mild agitation, weakness, or headache;
  • ringing in the ears;
  • nausea; or
  • loss of weight or appetite.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

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